Karachi se Lahore is a Pakistani romantic comedy movie. Zaeem, a boy who all his life has been mistreated by his parents, teacher, friends, bosses, neighbors and even by society loves his girlfriend Ayesha. Ayesha leaves for Lahore to meet her parents where her parents have planned her marriage with a cousin. When Zaeem comes know about this wedding taking place in Lahore, he along with his clan starts his journey from Karachi to Lahore via road to stop this marriage. They all have an ego problem with each other and try to resolve their conflicts with facing obstacles on the road too. Finally, they reach Lahore and try to stop the wedding but a twist has happened.